A big picture of Ebola Transmission during 2013-2016 outbreak can stop future outbreaks

days-since-last-case

Days since last case of Ebola at Guinea, Sierra Leone and Liberia (Courtesy: CDC)

A globalized effort by international team of scientists, clinicians, non-governmental organizations, drug companies and many more to eradicate Ebola that shook with vast West African epidemic was brought down in 2016. A review article co-authored with Dr. Aftab Ahmad and Mr. Sagar Aryal, we tried to depict about the Ebola Outbreak situation including the controversies and solutions. What was the situation of Ebola at the end of 2016? At Biomysteries you can follow the post “Where is Ebola now? 2016 update” to find the concluding situation of Ebola.

A recent research that published in the journal Nature on 12th April 2016, international group of scientists analyzed the entire database of Ebola virus genomes for 2013 to 2016 West African Epidemic. The analysis revealed about the epidemic unfolded in small overlapping outbreaks and spread by infected travelers incite new outbreak elsewhere, this is how the transmission chain continued. But in each case it represented a missed opportunity to break that chain of transmission to make the epidemic end sooner.

In West African Ebola outbreak caused massive transmission affecting nearly 28,000 people and killing 11,000 of them. The database revealed 1,610 Ebola virus genomes have more than 5 percent of known cases – this is the largest sample analyzed for human epidemic. Pushing back the previous analysis that was focused on only single country, this research was based on three primary countries – Guinea, Sierra Leone and Liberia that were more affected by Ebola.

Another hold or importance of the paper was the united collaboration from 86 scientists from 60 different institutions from 18 different countries authored this paper. Authors’ intention was to provide a complete framework for predicting future outbreak for Ebola Virus or other similar viral spread.

[youtube https://www.youtube.com/watch?v=j4Ut4krp8GQ&w=612&h=344%5D

Please find the video above here showing three countries (Guinea in green, Sierra Leone in Blue and Liberia in red) that were mostly affected in Ebola 2013-2016 epidemic. The differential shading defines weekly incidence rates of Ebola Virus disease. In association to that the evolutionary tree on right shows the relationships between sampled Ebola lineages.

Journal Source:

Dudas G, Carvalho L, Bedford T, Tatem A, Baele G, Faria N et al. Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature. 2017; doi:10.1038/nature22040

Further Reading:

Sarkar S. Where is Ebola now? 2016 update. Biomysteries https://biomysteries.wordpress.com/2016/07/08/where-is-ebola-now-2016-update/

Sarkar S, Aryal S, Ahmed A. The Ebola Outbreak – Controversies and Solutions 2014-15. International Journal of Microbiology and Allied Sciences. 2015; 1(4):10-17 (Link)

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About Saumyadip

Science Communicator and Biologist. Keep interests in host-pathogen interaction research. Specifically bacterial infection mechanism, host infection evasion and immune susceptibility of host. PhD student at Academia Sinica Molecular and Cell Biology, Taiwan
This entry was posted in Bioinformatics Tools, Molecular Biology and Genetics, Uncategorized, Virology and tagged , , , , , . Bookmark the permalink.

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